Drug interactions
Haloperidol + Stiripentol
Severity: Moderate
Haloperidol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes, including CYP3A4, CYP2D6 and CYP1A2, and may raise haloperidol concentrations. Both drugs cause sedation, so drowsiness and extrapyramidal effects may increase.
What this interaction means in plain words
Haloperidol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP enzymes involved in haloperidol metabolism, with additive CNS depression.
What to do
Monitor for sedation, extrapyramidal symptoms and QTc changes, and reduce haloperidol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Haloperidol with Stiripentol?
MediHelp rates the interaction as moderate. Haloperidol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes, including CYP3A4, CYP2D6 and CYP1A2, and may raise haloperidol concentrations. Both drugs cause sedation, so drowsiness and extrapyramidal effects may increase.
How serious is the interaction between Haloperidol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and QTc changes, and reduce haloperidol dose if adverse effects appear.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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