Drug interactions
Haloperidol + Valbenazine
Severity: Moderate
Haloperidol and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and haloperidol has a recognized torsades risk. Combined use may increase arrhythmia risk, and both can cause somnolence and parkinsonism.
What this interaction means in plain words
Haloperidol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, with overlapping dopamine-related effects.
What to do
Monitor ECG in patients with risk factors for QT prolongation and correct electrolyte disturbances. Watch for sedation and parkinsonism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Haloperidol with Valbenazine?
MediHelp rates the interaction as moderate. Haloperidol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and haloperidol has a recognized torsades risk. Combined use may increase arrhythmia risk, and both can cause somnolence and parkinsonism.
How serious is the interaction between Haloperidol and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with risk factors for QT prolongation and correct electrolyte disturbances. Watch for sedation and parkinsonism.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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