Drug interactions
Hawthorn + Vandetanib
Severity: Moderate
Hawthorn and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib markedly prolongs the QT interval and can cause torsades de pointes. Hawthorn has cardioactive effects but no well-established QT prolongation, so any additive effect is theoretical.
What this interaction means in plain words
Hawthorn and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hawthorn belongs to Gastrointestinal Tract; Vandetanib belongs to Oncology.
Why it happens
Possible additive cardiac electrophysiological effects; not well established for hawthorn.
What to do
Avoid unnecessary herbal cardiac supplements during vandetanib therapy. If used, monitor ECG and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hawthorn
- Amiodarone + Hawthorn Moderate
- Digoxin + Hawthorn Moderate
- Disopyramide + Hawthorn Moderate
- Encainide + Hawthorn Moderate
- Hawthorn + Ibutilide Moderate
- Hawthorn + Procainamide Moderate
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hawthorn with Vandetanib?
MediHelp rates the interaction as moderate. Hawthorn and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib markedly prolongs the QT interval and can cause torsades de pointes. Hawthorn has cardioactive effects but no well-established QT prolongation, so any additive effect is theoretical.
How serious is the interaction between Hawthorn and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary herbal cardiac supplements during vandetanib therapy. If used, monitor ECG and electrolytes.
What other medicines interact with Hawthorn?
MediHelp also lists interactions of Hawthorn with, for example, Amiodarone, Digoxin, Disopyramide. The full list is on the Hawthorn page.
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