Drug interactions
Hemin + Rivaroxaban
Severity: Moderate
Hemin and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin's degradation product hematin can cause transient coagulopathy and mild anticoagulant effects, which may add to the bleeding risk from rivaroxaban.
What this interaction means in plain words
Hemin and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hemin belongs to Miscellaneous; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of hematin's anticoagulant and platelet effects with factor Xa inhibition.
What to do
Monitor for bleeding and coagulation parameters and platelets during and after hemin infusion. Consider temporarily holding rivaroxaban if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Hemin with Rivaroxaban?
MediHelp rates the interaction as moderate. Hemin and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin's degradation product hematin can cause transient coagulopathy and mild anticoagulant effects, which may add to the bleeding risk from rivaroxaban.
How serious is the interaction between Hemin and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters and platelets during and after hemin infusion. Consider temporarily holding rivaroxaban if bleeding occurs.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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