Drug interactions
Human papillomavirus vaccine + Prednisone
Severity: Moderate
Human papillomavirus vaccine and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisone at higher doses or for extended periods can reduce vaccine responses. The HPV vaccine can be given, but protection may be lessened.
What this interaction means in plain words
Human papillomavirus vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Prednisone belongs to Endocrine.
Why it happens
Glucocorticoid suppression of lymphocyte activation and antibody production.
What to do
Vaccinate before prolonged high-dose therapy when possible; otherwise give on schedule and follow immunocompromised dosing recommendations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Human papillomavirus vaccine with Prednisone?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisone at higher doses or for extended periods can reduce vaccine responses. The HPV vaccine can be given, but protection may be lessened.
How serious is the interaction between Human papillomavirus vaccine and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before prolonged high-dose therapy when possible; otherwise give on schedule and follow immunocompromised dosing recommendations.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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