Drug interactions
Human papillomavirus vaccine + Ustekinumab
Severity: Minor
Human papillomavirus vaccine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab blocks IL-12 and IL-23 signalling, which may modestly alter vaccine responses. Inactivated vaccines are generally considered safe but protection is likely to be at least adequate in most patients.
What this interaction means in plain words
Human papillomavirus vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Human papillomavirus vaccine belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
IL-12/23 inhibition may dampen some T-cell-dependent immune responses to vaccination.
What to do
Inactivated HPV vaccine can be given, ideally before or between ustekinumab doses. Do not delay the vaccine series because of this.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Human papillomavirus vaccine with Ustekinumab?
MediHelp rates the interaction as minor. Human papillomavirus vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab blocks IL-12 and IL-23 signalling, which may modestly alter vaccine responses. Inactivated vaccines are generally considered safe but protection is likely to be at least adequate in most patients.
How serious is the interaction between Human papillomavirus vaccine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inactivated HPV vaccine can be given, ideally before or between ustekinumab doses. Do not delay the vaccine series because of this.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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