Drug interactions
Human papillomavirus vaccine + Voclosporin
Severity: Moderate
Human papillomavirus vaccine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that may blunt the immune response to the HPV vaccine. Protection after vaccination during treatment may be reduced.
What this interaction means in plain words
Human papillomavirus vaccine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent immune responses.
What to do
Complete vaccination at least 2 weeks before voclosporin when feasible. Consider checking antibody response or revaccinating if immunosuppression is later reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine with Voclosporin?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that may blunt the immune response to the HPV vaccine. Protection after vaccination during treatment may be reduced.
How serious is the interaction between Human papillomavirus vaccine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination at least 2 weeks before voclosporin when feasible. Consider checking antibody response or revaccinating if immunosuppression is later reduced.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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