Drug interactions
Hydrochlorothiazide + Indacaterol-glycopyrronium
Severity: Moderate
Hydrochlorothiazide and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-2 agonists such as indacaterol can lower serum potassium, and thiazide diuretics also cause potassium loss. Together they may produce clinically significant hypokalemia, which can promote cardiac arrhythmias, especially in patients with heart disease or hypoxia.
What this interaction means in plain words
Hydrochlorothiazide and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 agonist-driven intracellular potassium shift and thiazide-induced renal potassium loss.
What to do
Monitor serum potassium periodically, particularly at the start of therapy or in patients with cardiac disease. Replace potassium or magnesium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-2 agonists such as indacaterol can lower serum potassium, and thiazide diuretics also cause potassium loss. Together they may produce clinically significant hypokalemia, which can promote cardiac arrhythmias, especially in patients with heart disease or hypoxia.
How serious is the interaction between Hydrochlorothiazide and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, particularly at the start of therapy or in patients with cardiac disease. Replace potassium or magnesium if levels fall.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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