Drug interactions
Hydrochlorothiazide + Magnesium oxide
Severity: Minor
Hydrochlorothiazide and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide promotes renal magnesium wasting, which may reduce the benefit of magnesium supplementation or contribute to hypomagnesemia. This is generally a minor and manageable effect.
What this interaction means in plain words
Hydrochlorothiazide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Thiazide-induced increase in urinary magnesium excretion.
What to do
Monitor serum magnesium during prolonged therapy and adjust the supplement dose to the level.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide with Magnesium oxide?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide promotes renal magnesium wasting, which may reduce the benefit of magnesium supplementation or contribute to hypomagnesemia. This is generally a minor and manageable effect.
How serious is the interaction between Hydrochlorothiazide and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium during prolonged therapy and adjust the supplement dose to the level.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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