Drug interactions
Hydrochlorothiazide + Memantine
Severity: Minor
Hydrochlorothiazide and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated largely unchanged by the kidney, and hydrochlorothiazide may modestly reduce its clearance. Labeling lists hydrochlorothiazide among drugs that may alter memantine exposure, though clinical effect is usually small. Increased memantine adverse effects such as dizziness or confusion are possible.
What this interaction means in plain words
Hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular secretion via cationic transport pathways, with thiazide-related changes in renal handling.
What to do
No routine dose change is needed; monitor for dizziness, confusion or agitation, particularly in elderly patients or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Hydrochlorothiazide with Memantine?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated largely unchanged by the kidney, and hydrochlorothiazide may modestly reduce its clearance. Labeling lists hydrochlorothiazide among drugs that may alter memantine exposure, though clinical effect is usually small. Increased memantine adverse effects such as dizziness or confusion are possible.
How serious is the interaction between Hydrochlorothiazide and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for dizziness, confusion or agitation, particularly in elderly patients or those with renal impairment.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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