Drug interactions
Hydrochlorothiazide + Piroxicam
Severity: Moderate
Hydrochlorothiazide and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can reduce the diuretic and antihypertensive effects of hydrochlorothiazide. The combination also raises the risk of reduced renal function, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing thiazide action.
What to do
Monitor blood pressure, fluid status, serum creatinine and electrolytes. Ensure adequate hydration and use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Piroxicam?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can reduce the diuretic and antihypertensive effects of hydrochlorothiazide. The combination also raises the risk of reduced renal function, particularly in elderly or volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, serum creatinine and electrolytes. Ensure adequate hydration and use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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