Drug interactions
Hydrochlorothiazide + Saxagliptin
Severity: Minor
Hydrochlorothiazide and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may reduce the glycemic benefit of saxagliptin. The effect is usually modest.
What this interaction means in plain words
Hydrochlorothiazide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Thiazides impair glucose tolerance via hypokalemia and reduced insulin secretion, opposing the antihyperglycemic effect (pharmacodynamic antagonism).
What to do
Monitor blood glucose when starting or changing the thiazide and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Hydrochlorothiazide with Saxagliptin?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may reduce the glycemic benefit of saxagliptin. The effect is usually modest.
How serious is the interaction between Hydrochlorothiazide and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the thiazide and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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