Drug interactions
Hydrochlorothiazide-irbesartan + Labetalol
Severity: Minor
Hydrochlorothiazide-irbesartan and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol adds to the blood pressure lowering effect of irbesartan and hydrochlorothiazide, which may cause hypotension or dizziness. This is usually a planned combination, but dose adjustment may be needed.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through alpha/beta adrenergic blockade, RAAS blockade and diuresis.
What to do
Monitor blood pressure and heart rate, especially at initiation or dose increases, and adjust doses accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Labetalol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labetalol adds to the blood pressure lowering effect of irbesartan and hydrochlorothiazide, which may cause hypotension or dizziness. This is usually a planned combination, but dose adjustment may be needed.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially at initiation or dose increases, and adjust doses accordingly.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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