Drug interactions
Hydrochlorothiazide-irbesartan + Liraglutide
Severity: Minor
Hydrochlorothiazide-irbesartan and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan may modestly improve insulin sensitivity and add to glucose lowering with liraglutide, whereas thiazides may raise glucose. Overall effect on glycemic control is small and variable.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
ARB-related improvement in insulin sensitivity versus thiazide-induced impaired glucose tolerance; the net effect is not well defined.
What to do
Monitor blood glucose when starting or changing therapy and adjust antidiabetic treatment if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Liraglutide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irbesartan may modestly improve insulin sensitivity and add to glucose lowering with liraglutide, whereas thiazides may raise glucose. Overall effect on glycemic control is small and variable.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing therapy and adjust antidiabetic treatment if needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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