Drug interactions
Hydrochlorothiazide-irbesartan + Lonafarnib
Severity: Minor
Hydrochlorothiazide-irbesartan and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and the concern is about CYP3A inhibitors. Irbesartan is not a meaningful CYP3A inhibitor, so an increase in lonafarnib exposure is unlikely.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
No established pharmacokinetic mechanism; irbesartan is not a recognised CYP3A inhibitor.
What to do
No dose adjustment is needed; monitor for arrhythmia symptoms and electrolytes, especially with the thiazide component.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Lonafarnib?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, and the concern is about CYP3A inhibitors. Irbesartan is not a meaningful CYP3A inhibitor, so an increase in lonafarnib exposure is unlikely.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for arrhythmia symptoms and electrolytes, especially with the thiazide component.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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