Drug interactions
Hydrochlorothiazide-irbesartan + Lurasidone
Severity: Moderate
Hydrochlorothiazide-irbesartan and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 blocking activity that may cause orthostatic hypotension, which can add to the blood pressure lowering of irbesartan and hydrochlorothiazide. Dizziness and falls may occur, especially at initiation.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from antipsychotic alpha-1 adrenergic antagonism and antihypertensive therapy.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing lurasidone, and reduce antihypertensive doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Lurasidone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 blocking activity that may cause orthostatic hypotension, which can add to the blood pressure lowering of irbesartan and hydrochlorothiazide. Dizziness and falls may occur, especially at initiation.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing lurasidone, and reduce antihypertensive doses if needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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