Drug interactions
Hydrochlorothiazide-irbesartan + Magnesium oxide
Severity: Minor
Hydrochlorothiazide-irbesartan and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can increase urinary magnesium loss and cause hypomagnesemia. Magnesium oxide supplementation may offset this, so the interaction is generally of limited concern.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Hydrochlorothiazide increases renal magnesium excretion.
What to do
Monitor serum magnesium during long-term thiazide use and adjust the supplement dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Magnesium oxide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can increase urinary magnesium loss and cause hypomagnesemia. Magnesium oxide supplementation may offset this, so the interaction is generally of limited concern.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium during long-term thiazide use and adjust the supplement dose accordingly.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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