Drug interactions
Hydrochlorothiazide-irbesartan + Memantine
Severity: Minor
Hydrochlorothiazide-irbesartan and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may reduce renal elimination of memantine, and the labeling notes that HCTZ combinations can lower its exposure. Clinical consequences are uncertain and likely small, though memantine adverse effects such as dizziness or confusion may occur.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular secretion; the exact effect is not well established.
What to do
No dose change is usually needed. Monitor for memantine adverse effects such as dizziness or confusion, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Memantine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may reduce renal elimination of memantine, and the labeling notes that HCTZ combinations can lower its exposure. Clinical consequences are uncertain and likely small, though memantine adverse effects such as dizziness or confusion may occur.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for memantine adverse effects such as dizziness or confusion, particularly in renal impairment.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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