Drug interactions
Hydrochlorothiazide-irbesartan + Succinylcholine
Severity: Moderate
Hydrochlorothiazide-irbesartan and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can transiently raise serum potassium, whereas hydrochlorothiazide commonly causes hypokalemia and electrolyte disturbance. Electrolyte imbalance may alter neuromuscular blockade and arrhythmia risk during anesthesia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Succinylcholine-induced potassium efflux from muscle contrasts with thiazide-induced potassium depletion, and electrolyte disturbances modify neuromuscular and cardiac responses.
What to do
Check serum potassium and magnesium before anesthesia and correct abnormalities. Monitor neuromuscular function and ECG during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-irbesartan and Succinylcholine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Succinylcholine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can transiently raise serum potassium, whereas hydrochlorothiazide commonly causes hypokalemia and electrolyte disturbance. Electrolyte imbalance may alter neuromuscular blockade and arrhythmia risk during anesthesia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before anesthesia and correct abnormalities. Monitor neuromuscular function and ECG during the procedure.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
