Drug interactions
Hydrochlorothiazide-lisinopril + Methylprednisolone
Severity: Moderate
Hydrochlorothiazide-lisinopril and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and corticosteroids promote potassium loss, so combining them raises the risk of hypokalemia. Corticosteroids may also blunt the blood pressure-lowering effect through sodium and fluid retention.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Methylprednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting and corticosteroid-induced sodium and water retention.
What to do
Monitor serum potassium and blood pressure, and replace potassium if needed. The ACE inhibitor component may partly offset the potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Methylprednisolone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and corticosteroids promote potassium loss, so combining them raises the risk of hypokalemia. Corticosteroids may also blunt the blood pressure-lowering effect through sodium and fluid retention.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and replace potassium if needed. The ACE inhibitor component may partly offset the potassium loss.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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