Drug interactions
Hydrochlorothiazide-lisinopril + Metolazone
Severity: Major
Hydrochlorothiazide-lisinopril and Metolazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone is a thiazide-like diuretic that acts synergistically with hydrochlorothiazide through sequential or duplicate sodium reabsorption blockade. This can cause profound diuresis, hypokalemia, hyponatremia, hypotension, and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Metolazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Duplicate thiazide-class inhibition of distal tubular sodium chloride reabsorption produces additive natriuresis and potassium loss.
What to do
Avoid combining two thiazide-type diuretics unless deliberately used for resistant edema under supervision. If used, monitor electrolytes, renal function, weight, and blood pressure frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-lisinopril and Metolazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Metolazone
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Metolazone?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Metolazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metolazone is a thiazide-like diuretic that acts synergistically with hydrochlorothiazide through sequential or duplicate sodium reabsorption blockade. This can cause profound diuresis, hypokalemia, hyponatremia, hypotension, and renal impairment.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Metolazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics unless deliberately used for resistant edema under supervision. If used, monitor electrolytes, renal function, weight, and blood pressure frequently.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
