Drug interactions
Hydrochlorothiazide-lisinopril + Midodrine
Severity: Moderate
Hydrochlorothiazide-lisinopril and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine raises blood pressure and so opposes the antihypertensive effect of this combination. Competition for tubular secretion is theoretical and has little clinical importance.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Midodrine belongs to Miscellaneous.
Why it happens
Pharmacodynamic opposition of vasopressor and antihypertensive effects; minor possible competition for renal secretion.
What to do
Monitor supine and standing blood pressure and reassess whether both therapies are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Midodrine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine raises blood pressure and so opposes the antihypertensive effect of this combination. Competition for tubular secretion is theoretical and has little clinical importance.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and reassess whether both therapies are needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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