Drug interactions
Hydrochlorothiazide-losartan + Leflunomide
Severity: Minor
Hydrochlorothiazide-losartan and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide's metabolite teriflunomide may inhibit CYP2C9 and could reduce formation of losartan's active metabolite. The clinical importance is uncertain, and antihypertensive response may change slightly.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Leflunomide belongs to Musculoskeletal.
Why it happens
Teriflunomide inhibits CYP2C9, which may reduce conversion of losartan to its active metabolite E-3174.
What to do
No routine dose change is needed. Monitor blood pressure after starting or stopping leflunomide and adjust losartan if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Leflunomide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide's metabolite teriflunomide may inhibit CYP2C9 and could reduce formation of losartan's active metabolite. The clinical importance is uncertain, and antihypertensive response may change slightly.
How serious is the interaction between Hydrochlorothiazide-losartan and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure after starting or stopping leflunomide and adjust losartan if control changes.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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