Drug interactions
Hydrochlorothiazide-losartan + Maraviroc
Severity: Moderate
Hydrochlorothiazide-losartan and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension, and this may be additive with antihypertensive drugs. Patients taking losartan and hydrochlorothiazide may experience more dizziness or fainting, particularly when changing position.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Maraviroc belongs to Anti Virals.
Why it happens
Additive hypotensive effects, with maraviroc contributing postural hypotension.
What to do
Monitor blood pressure and orthostatic symptoms when starting maraviroc, and adjust antihypertensive doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Maraviroc?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc can cause postural hypotension, and this may be additive with antihypertensive drugs. Patients taking losartan and hydrochlorothiazide may experience more dizziness or fainting, particularly when changing position.
How serious is the interaction between Hydrochlorothiazide-losartan and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting maraviroc, and adjust antihypertensive doses if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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