Drug interactions
Hydrochlorothiazide-losartan + Tucatinib
Severity: Minor
Hydrochlorothiazide-losartan and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A inhibitor and may reduce conversion of losartan to its active metabolite, with a modest effect on blood pressure. Losartan is not an established CYP2C8 inhibitor, so tucatinib exposure is unlikely to change.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
CYP3A inhibition by tucatinib may alter losartan activation; no meaningful effect of losartan on tucatinib metabolism is expected.
What to do
Monitor blood pressure after starting tucatinib and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Tucatinib?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib is a CYP3A inhibitor and may reduce conversion of losartan to its active metabolite, with a modest effect on blood pressure. Losartan is not an established CYP2C8 inhibitor, so tucatinib exposure is unlikely to change.
How serious is the interaction between Hydrochlorothiazide-losartan and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting tucatinib and adjust antihypertensive therapy if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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