Drug interactions
Hydrocodone + Lisdexamfetamine
Severity: Moderate
Hydrocodone and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines enhance monoaminergic transmission and with opioids may contribute to serotonin toxicity. They can also mask opioid sedation.
What this interaction means in plain words
Hydrocodone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Amphetamine-induced monoamine release adds to opioid serotonergic activity.
What to do
Monitor for serotonin syndrome and cardiovascular effects during initiation and dose changes. Counsel patients on impaired psychomotor function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Hydrocodone with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Hydrocodone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines enhance monoaminergic transmission and with opioids may contribute to serotonin toxicity. They can also mask opioid sedation.
How serious is the interaction between Hydrocodone and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and cardiovascular effects during initiation and dose changes. Counsel patients on impaired psychomotor function.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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