Drug interactions
Hydrocodone + Tasimelteon
Severity: Minor
Hydrocodone and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon is a melatonin receptor agonist that can cause drowsiness, and combined with an opioid it may add to sedation. Significant respiratory depression from tasimelteon itself is not established.
What this interaction means in plain words
Hydrocodone and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Tasimelteon belongs to Central Nervous System.
Why it happens
Possible additive sedation; tasimelteon has limited intrinsic respiratory depressant activity.
What to do
Counsel patients about drowsiness and avoid driving until response is known. Monitor for excessive sedation, especially when opioid doses are high.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Tasimelteon
Frequently asked questions
Can I take Hydrocodone with Tasimelteon?
MediHelp rates the interaction as minor. Hydrocodone and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon is a melatonin receptor agonist that can cause drowsiness, and combined with an opioid it may add to sedation. Significant respiratory depression from tasimelteon itself is not established.
How serious is the interaction between Hydrocodone and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoid driving until response is known. Monitor for excessive sedation, especially when opioid doses are high.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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