Drug interactions
Hydromorphone + Modafinil
Severity: Minor
Hydromorphone and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness and may partly counter hydromorphone sedation, though the net effect is unpredictable. Modafinil also weakly induces CYP3A4, which is not a major route for hydromorphone, so no important pharmacokinetic effect is expected.
What this interaction means in plain words
Hydromorphone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydromorphone belongs to Musculoskeletal; Modafinil belongs to Central Nervous System.
Why it happens
Opposing effects on arousal; no established pharmacokinetic mechanism of significance.
What to do
Monitor analgesia and respiratory status; do not use modafinil to reverse opioid sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Hydromorphone with Modafinil?
MediHelp rates the interaction as minor. Hydromorphone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness and may partly counter hydromorphone sedation, though the net effect is unpredictable. Modafinil also weakly induces CYP3A4, which is not a major route for hydromorphone, so no important pharmacokinetic effect is expected.
How serious is the interaction between Hydromorphone and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia and respiratory status; do not use modafinil to reverse opioid sedation.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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