Drug interactions
Hydromorphone + Ozanimod
Severity: Moderate
Hydromorphone and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's metabolite inhibits MAO-B in vitro, and MAO inhibitors can cause serious reactions with some opioids. Hydromorphone is not strongly serotonergic, so the risk is likely lower than with meperidine or tramadol, but blood pressure effects remain a theoretical concern.
What this interaction means in plain words
Hydromorphone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by the ozanimod metabolite may potentiate adrenergic or serotonergic effects; this is theoretical for hydromorphone.
What to do
Monitor blood pressure, heart rate and signs of serotonin toxicity when starting or adjusting either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Hydromorphone with Ozanimod?
MediHelp rates the interaction as moderate. Hydromorphone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's metabolite inhibits MAO-B in vitro, and MAO inhibitors can cause serious reactions with some opioids. Hydromorphone is not strongly serotonergic, so the risk is likely lower than with meperidine or tramadol, but blood pressure effects remain a theoretical concern.
How serious is the interaction between Hydromorphone and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of serotonin toxicity when starting or adjusting either drug.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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