Drug interactions
Hydromorphone + Pregabalin
Severity: Major
Hydromorphone and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin with hydromorphone produces additive sedation and may cause respiratory depression. The risk is greater in older patients, those with renal or respiratory disease, and at higher doses.
What this interaction means in plain words
Hydromorphone and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydromorphone belongs to Musculoskeletal; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Start both agents at low doses and titrate slowly. Monitor for excessive sedation and slowed breathing, and reduce doses if these occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Hydromorphone with Pregabalin?
MediHelp rates the interaction as major. Hydromorphone and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin with hydromorphone produces additive sedation and may cause respiratory depression. The risk is greater in older patients, those with renal or respiratory disease, and at higher doses.
How serious is the interaction between Hydromorphone and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start both agents at low doses and titrate slowly. Monitor for excessive sedation and slowed breathing, and reduce doses if these occur.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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