Drug interactions
Hydromorphone + Stiripentol
Severity: Moderate
Hydromorphone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence and, when taken with an opioid like hydromorphone, central depressant effects may be additive. This can increase drowsiness, dizziness and, at higher doses, respiratory depression.
What this interaction means in plain words
Hydromorphone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Start hydromorphone at the lowest effective dose and monitor for sedation and respiratory depression, particularly after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Hydromorphone with Stiripentol?
MediHelp rates the interaction as moderate. Hydromorphone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence and, when taken with an opioid like hydromorphone, central depressant effects may be additive. This can increase drowsiness, dizziness and, at higher doses, respiratory depression.
How serious is the interaction between Hydromorphone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start hydromorphone at the lowest effective dose and monitor for sedation and respiratory depression, particularly after dose changes.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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