Drug interactions
Hydromorphone + Vortioxetine
Severity: Moderate
Hydromorphone and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine has multimodal serotonergic activity, so combining it with opioids carries a theoretical risk of serotonin syndrome. Hydromorphone has little serotonergic activity, so the risk is low, though sedation may be additive.
What this interaction means in plain words
Hydromorphone and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect; this is largely theoretical for hydromorphone.
What to do
Monitor for signs of serotonin syndrome and sedation when starting or increasing either drug. Discontinue both and provide supportive care if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Vortioxetine?
MediHelp rates the interaction as moderate. Hydromorphone and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine has multimodal serotonergic activity, so combining it with opioids carries a theoretical risk of serotonin syndrome. Hydromorphone has little serotonergic activity, so the risk is low, though sedation may be additive.
How serious is the interaction between Hydromorphone and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and sedation when starting or increasing either drug. Discontinue both and provide supportive care if toxicity occurs.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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