Drug interactions
Hydroxycarbamide + Temozolomide
Severity: Moderate
Hydroxycarbamide and Temozolomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress the bone marrow, and temozolomide can cause delayed thrombocytopenia and neutropenia. The combination may deepen cytopenias and raise the risk of infection and bleeding.
What this interaction means in plain words
Hydroxycarbamide and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Temozolomide belongs to Oncology.
Why it happens
Additive myelosuppression from an alkylating agent and an antimetabolite.
What to do
Monitor complete blood counts regularly, including nadir values. Reduce doses or delay cycles if counts do not recover.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydroxycarbamide and Temozolomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Temozolomide
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Hydroxycarbamide with Temozolomide?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress the bone marrow, and temozolomide can cause delayed thrombocytopenia and neutropenia. The combination may deepen cytopenias and raise the risk of infection and bleeding.
How serious is the interaction between Hydroxycarbamide and Temozolomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, including nadir values. Reduce doses or delay cycles if counts do not recover.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
