Drug interactions
Hydroxychloroquine + Indacaterol-glycopyrronium
Severity: Moderate
Hydroxychloroquine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can prolong the QT interval and indacaterol, as a beta-2 agonist, may add to this effect and promote hypokalemia. The combination may raise the risk of ventricular arrhythmias, particularly in patients with other risk factors.
What this interaction means in plain words
Hydroxychloroquine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia and sympathetic stimulation increasing arrhythmia susceptibility.
What to do
Obtain a baseline ECG and correct potassium and magnesium before and during co-use. Avoid in patients with congenital long QT syndrome or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can prolong the QT interval and indacaterol, as a beta-2 agonist, may add to this effect and promote hypokalemia. The combination may raise the risk of ventricular arrhythmias, particularly in patients with other risk factors.
How serious is the interaction between Hydroxychloroquine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before and during co-use. Avoid in patients with congenital long QT syndrome or other QT-prolonging drugs.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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