Drug interactions
hydroxychloroquine + loperamide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Potential additive QTc prolongation and torsades risk; loperamide’s QT liability is conditional but may be clinically relevant with another known QT‑prolonging agent and patient risk factors.
Mechanism of action
Additive hERG/IKr blockade leading to QT prolongation; loperamide risk is dose‑ and condition‑dependent.
Clinical management
If coadministered, limit loperamide to labeled doses, avoid other QT‑prolongers, correct electrolytes, and consider ECG monitoring in patients with risk factors.
Drug reference
References
- QTdrugs List: Loperamide — Conditional Risk of TdP — CredibleMeds
- QTdrugs List: Hydroxychloroquine — Known Risk of TdP — CredibleMeds
- Plaquenil (hydroxychloroquine sulfate) Prescribing Information (QT prolongation warning) — FDA Label
Frequently asked questions
Can I take hydroxychloroquine with loperamide?
The interaction is rated: Moderate. Potential additive QTc prolongation and torsades risk; loperamide’s QT liability is conditional but may be clinically relevant with another known QT‑prolonging agent and patient risk factors.
How serious is the interaction between hydroxychloroquine and loperamide?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between hydroxychloroquine and loperamide managed?
If coadministered, limit loperamide to labeled doses, avoid other QT‑prolongers, correct electrolytes, and consider ECG monitoring in patients with risk factors.
Why do hydroxychloroquine and loperamide interact?
Additive hERG/IKr blockade leading to QT prolongation; loperamide risk is dose‑ and condition‑dependent.
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