Drug interactions
Hydroxychloroquine + Osilodrostat
Severity: Moderate
Hydroxychloroquine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so using them together may increase the risk of torsades de pointes. The risk is greater with hypokalemia, bradycardia, or other QT-prolonging drugs.
What this interaction means in plain words
Hydroxychloroquine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Obtain a baseline ECG and repeat it after starting or changing doses, and keep potassium and magnesium in the normal range. Osilodrostat can cause hypokalemia, so monitor electrolytes regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Hydroxychloroquine with Osilodrostat?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so using them together may increase the risk of torsades de pointes. The risk is greater with hypokalemia, bradycardia, or other QT-prolonging drugs.
How serious is the interaction between Hydroxychloroquine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting or changing doses, and keep potassium and magnesium in the normal range. Osilodrostat can cause hypokalemia, so monitor electrolytes regularly.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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