Drug interactions
Hydroxychloroquine + Osimertinib
Severity: Moderate
Hydroxychloroquine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and hydroxychloroquine has a similar effect. Together they may increase the chance of arrhythmia, particularly in patients with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Hydroxychloroquine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG and electrolytes and repeat periodically; correct potassium and magnesium, and consider an alternative if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Hydroxychloroquine with Osimertinib?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, and hydroxychloroquine has a similar effect. Together they may increase the chance of arrhythmia, particularly in patients with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Hydroxychloroquine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat periodically; correct potassium and magnesium, and consider an alternative if QTc becomes significantly prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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