Drug interactions
Hydroxychloroquine + Oxaliplatin
Severity: Major
Hydroxychloroquine and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation, and hydroxychloroquine may add to this risk. Oxaliplatin can also cause electrolyte disturbances and vomiting that further predispose to arrhythmia.
What this interaction means in plain words
Hydroxychloroquine and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxychloroquine belongs to Musculoskeletal; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation, with chemotherapy-related electrolyte loss increasing susceptibility.
What to do
Monitor ECG and serum potassium, magnesium and calcium during treatment, and correct deficits before each oxaliplatin cycle.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Oxaliplatin?
MediHelp rates the interaction as major. Hydroxychloroquine and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaliplatin has been associated with QT prolongation, and hydroxychloroquine may add to this risk. Oxaliplatin can also cause electrolyte disturbances and vomiting that further predispose to arrhythmia.
How serious is the interaction between Hydroxychloroquine and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, magnesium and calcium during treatment, and correct deficits before each oxaliplatin cycle.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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