Drug interactions
Hydroxychloroquine + Sirolimus
Severity: Minor
Hydroxychloroquine and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is a potent immunosuppressant, whereas hydroxychloroquine has only mild immunomodulatory effects and is not clearly immunosuppressive. The combination is commonly used in practice, and no important additive infection risk is established beyond that of sirolimus itself.
What this interaction means in plain words
Hydroxychloroquine and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxychloroquine belongs to Musculoskeletal; Sirolimus belongs to Miscellaneous.
Why it happens
Minimal additive immunomodulation; no established pharmacokinetic interaction.
What to do
No change in therapy is usually needed; continue routine monitoring for infection and sirolimus trough levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydroxychloroquine and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Sirolimus?
MediHelp rates the interaction as minor. Hydroxychloroquine and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus is a potent immunosuppressant, whereas hydroxychloroquine has only mild immunomodulatory effects and is not clearly immunosuppressive. The combination is commonly used in practice, and no important additive infection risk is established beyond that of sirolimus itself.
How serious is the interaction between Hydroxychloroquine and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in therapy is usually needed; continue routine monitoring for infection and sirolimus trough levels.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
