Drug interactions
Hydroxychloroquine + Voriconazole
Severity: Major
Hydroxychloroquine and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, and combining them raises the risk of torsades de pointes. Voriconazole may also modestly raise exposure to some co-administered drugs, adding to the concern in patients with cardiac risk factors.
What this interaction means in plain words
Hydroxychloroquine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxychloroquine belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Additive inhibition of cardiac potassium channels causing QTc prolongation.
What to do
Avoid the combination if an alternative exists. If it is unavoidable, check a baseline and follow-up ECG and correct hypokalemia and hypomagnesemia before and during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Voriconazole?
MediHelp rates the interaction as major. Hydroxychloroquine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are associated with QT prolongation, and combining them raises the risk of torsades de pointes. Voriconazole may also modestly raise exposure to some co-administered drugs, adding to the concern in patients with cardiac risk factors.
How serious is the interaction between Hydroxychloroquine and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, check a baseline and follow-up ECG and correct hypokalemia and hypomagnesemia before and during therapy.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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