Drug interactions
Hydroxyurea + Mitomycin
Severity: Moderate
Hydroxyurea and Mitomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive, and mitomycin in particular can cause delayed, cumulative marrow toxicity. Combined use increases the risk of severe cytopenias, infection and bleeding.
What this interaction means in plain words
Hydroxyurea and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Mitomycin belongs to Oncology.
Why it happens
Additive bone marrow suppression from two cytotoxic drugs.
What to do
Check complete blood counts regularly, including after treatment because of delayed nadirs. Reduce doses or delay treatment for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyurea
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Hydroxyurea with Mitomycin?
MediHelp rates the interaction as moderate. Hydroxyurea and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive, and mitomycin in particular can cause delayed, cumulative marrow toxicity. Combined use increases the risk of severe cytopenias, infection and bleeding.
How serious is the interaction between Hydroxyurea and Mitomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts regularly, including after treatment because of delayed nadirs. Reduce doses or delay treatment for significant cytopenias.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
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