Drug interactions
Hydroxyzine + Hyoscyamine
Severity: Moderate
Hydroxyzine and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combining them can intensify dry mouth, constipation, urinary retention, blurred vision and confusion. Older adults are especially vulnerable.
What this interaction means in plain words
Hydroxyzine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Monitor for anticholinergic toxicity, particularly cognitive effects and urinary retention in the elderly. Use lower doses or choose a non-anticholinergic alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hydroxyzine with Hyoscyamine?
MediHelp rates the interaction as moderate. Hydroxyzine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combining them can intensify dry mouth, constipation, urinary retention, blurred vision and confusion. Older adults are especially vulnerable.
How serious is the interaction between Hydroxyzine and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly cognitive effects and urinary retention in the elderly. Use lower doses or choose a non-anticholinergic alternative where possible.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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