Drug interactions
Hydroxyzine + Methamphetamine
Severity: Minor
Hydroxyzine and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine may mask hydroxyzine sedation, and the net effect on alertness is unpredictable. Hydroxyzine can also prolong the QT interval, and stimulant-induced tachycardia may add to cardiac concerns in susceptible patients.
What this interaction means in plain words
Hydroxyzine and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxyzine belongs to Respiratory; Methamphetamine belongs to Central Nervous System.
Why it happens
Opposing CNS effects of a stimulant and a sedating antihistamine, with possible additive cardiac effects.
What to do
No routine change is needed; counsel about driving and consider an ECG if the patient has QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Methamphetamine?
MediHelp rates the interaction as minor. Hydroxyzine and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methamphetamine may mask hydroxyzine sedation, and the net effect on alertness is unpredictable. Hydroxyzine can also prolong the QT interval, and stimulant-induced tachycardia may add to cardiac concerns in susceptible patients.
How serious is the interaction between Hydroxyzine and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel about driving and consider an ECG if the patient has QT risk factors.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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