Drug interactions
Hydroxyzine + Midostaurin
Severity: Major
Hydroxyzine and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin can prolong the QT interval, and hydroxyzine has a similar effect, so the combination may increase the likelihood of torsades de pointes.
What this interaction means in plain words
Hydroxyzine and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyzine belongs to Respiratory; Midostaurin belongs to Oncology.
Why it happens
Additive QT prolongation through delayed ventricular repolarization.
What to do
Use a non-QT-prolonging alternative to hydroxyzine where possible. If co-use is necessary, monitor ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Hydroxyzine with Midostaurin?
MediHelp rates the interaction as major. Hydroxyzine and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin can prolong the QT interval, and hydroxyzine has a similar effect, so the combination may increase the likelihood of torsades de pointes.
How serious is the interaction between Hydroxyzine and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging alternative to hydroxyzine where possible. If co-use is necessary, monitor ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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