Drug interactions
Hydroxyzine + Modafinil
Severity: Minor
Hydroxyzine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine and modafinil is wake-promoting, so their effects counteract each other. Modafinil may mask sleepiness without fully reversing psychomotor impairment.
What this interaction means in plain words
Hydroxyzine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxyzine belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal.
What to do
Counsel on driving and machinery risks, and consider a non-sedating alternative if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Modafinil?
MediHelp rates the interaction as minor. Hydroxyzine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyzine is a sedating antihistamine and modafinil is wake-promoting, so their effects counteract each other. Modafinil may mask sleepiness without fully reversing psychomotor impairment.
How serious is the interaction between Hydroxyzine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on driving and machinery risks, and consider a non-sedating alternative if sedation is troublesome.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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