Drug interactions
Hydroxyzine + Ozanimod
Severity: Moderate
Hydroxyzine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can cause heart rate slowing and conduction effects, and hydroxyzine can prolong QT; bradycardia increases the risk of torsades de pointes. The combination is therefore potentially arrhythmogenic.
What this interaction means in plain words
Hydroxyzine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Ozanimod belongs to Central Nervous System.
Why it happens
Bradycardia from S1P receptor modulation may add to hydroxyzine-related QT prolongation.
What to do
Obtain a baseline ECG and heart rate before use, and monitor for bradycardia or QT prolongation. Consider an alternative to hydroxyzine in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Hydroxyzine with Ozanimod?
MediHelp rates the interaction as moderate. Hydroxyzine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can cause heart rate slowing and conduction effects, and hydroxyzine can prolong QT; bradycardia increases the risk of torsades de pointes. The combination is therefore potentially arrhythmogenic.
How serious is the interaction between Hydroxyzine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and heart rate before use, and monitor for bradycardia or QT prolongation. Consider an alternative to hydroxyzine in patients with cardiac risk factors.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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