Drug interactions
Hydroxyzine + Pregabalin
Severity: Moderate
Hydroxyzine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine and pregabalin both cause sedation, so together they can produce excessive drowsiness, dizziness and impaired psychomotor performance. Respiratory depression is possible, especially in older or medically compromised patients.
What this interaction means in plain words
Hydroxyzine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression from pregabalin and the sedating antihistamine hydroxyzine.
What to do
Start with low doses and titrate carefully, advising patients to avoid driving until the response is known. Monitor for sedation and respiratory depression, particularly in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Pregabalin?
MediHelp rates the interaction as moderate. Hydroxyzine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine and pregabalin both cause sedation, so together they can produce excessive drowsiness, dizziness and impaired psychomotor performance. Respiratory depression is possible, especially in older or medically compromised patients.
How serious is the interaction between Hydroxyzine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate carefully, advising patients to avoid driving until the response is known. Monitor for sedation and respiratory depression, particularly in the elderly.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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