Drug interactions
Hydroxyzine + Ranolazine
Severity: Moderate
Hydroxyzine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine has been associated with QT prolongation and torsades de pointes, and ranolazine also lengthens the QT interval. The combination increases arrhythmia risk, especially in older patients or those with electrolyte disturbances.
What this interaction means in plain words
Hydroxyzine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Ranolazine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Use the lowest effective hydroxyzine dose for the shortest time and monitor the ECG in at-risk patients. Prefer a non-QT-prolonging antihistamine or anxiolytic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Ranolazine?
MediHelp rates the interaction as moderate. Hydroxyzine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine has been associated with QT prolongation and torsades de pointes, and ranolazine also lengthens the QT interval. The combination increases arrhythmia risk, especially in older patients or those with electrolyte disturbances.
How serious is the interaction between Hydroxyzine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose for the shortest time and monitor the ECG in at-risk patients. Prefer a non-QT-prolonging antihistamine or anxiolytic where possible.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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