Drug interactions
Hydroxyzine + Sevoflurane
Severity: Moderate
Hydroxyzine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can prolong the QT interval and cause torsades de pointes, and sevoflurane also affects repolarization. Hydroxyzine used as premedication adds sedation, so the combination warrants attention to both rhythm and depth of anesthesia.
What this interaction means in plain words
Hydroxyzine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation plus additive CNS depression.
What to do
Check the baseline QTc and correct electrolytes before giving hydroxyzine premedication. Monitor the ECG during anesthesia and avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Sevoflurane?
MediHelp rates the interaction as moderate. Hydroxyzine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine can prolong the QT interval and cause torsades de pointes, and sevoflurane also affects repolarization. Hydroxyzine used as premedication adds sedation, so the combination warrants attention to both rhythm and depth of anesthesia.
How serious is the interaction between Hydroxyzine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct electrolytes before giving hydroxyzine premedication. Monitor the ECG during anesthesia and avoid other QT-prolonging drugs where possible.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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