Drug interactions
Hydroxyzine + Stiripentol
Severity: Moderate
Hydroxyzine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence, and hydroxyzine is a sedating antihistamine. Together they can increase drowsiness and impair psychomotor performance.
What this interaction means in plain words
Hydroxyzine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and counsel patients about driving and machinery. Reduce the hydroxyzine dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Hydroxyzine with Stiripentol?
MediHelp rates the interaction as moderate. Hydroxyzine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence, and hydroxyzine is a sedating antihistamine. Together they can increase drowsiness and impair psychomotor performance.
How serious is the interaction between Hydroxyzine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients about driving and machinery. Reduce the hydroxyzine dose if sedation is troublesome.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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